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2010/05/19
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berita emas:
- Recurrent Vulvovaginal Candidiasis: An Immunological Perspective - MDPI
This review provides an overview of the current understanding of the host immune response in VVC pathogenesis and suggests that a tightly regulated fungus–host–microbiota interplay might exert a protective role against recurrent Candida infections
- Frontiers | It Takes Two to Tango: How a Dysregulation of the Innate . . .
As mentioned above, VVC and RVVC are not immunodeficiency-associated conditions (Jabra-Rizk et al , 2016), but they are rather linked to predisposing factors such as high oral estrogen administration for contraceptive purposes, hormone replacement therapy, prolonged antibiotic usage, and underlying diabetes mellitus (McClelland et al , 2009
- Novel Mechanism behind the Immunopathogenesis of Vulvovaginal . . .
Importantly, VVC and RVVC are not associated with immunodeficiency but instead are associated with a vigorous local acute inflammatory response This minireview covers the history of the investigations of host defense in VVC that ultimately led to the elusive mechanism of the immunopathogenic response
- The Mechanism of IL-17 Regulating Neutrophils Participating . . . - Springer
However, the role of IL-17 in local immunity in VVC and RVVC is poorly understood At the same time, neutrophils are considered the most effective way to control and eliminate candidal infection and have a controversial role in VVC and RVVC In this study, we built a mouse RVVC model
- An Exaggerated Monocyte-Derived Cytokine Response to
Women affected by RVVC showed increased monocytes-derived cytokine production, which might contribute to an exaggerated vaginal immune response to Candida hyphae RVVC patients show no defective Th-dependent adaptive immune response upon Candida stimulation
- It takes two to tango: how a dysregulation of the innate immunity . . .
As mentioned above, VVC and RVVC are not immunodeficiency-associated conditions (Jabra-Rizk et al , 2016), but they are rather linked to predisposing factors such as high oral estrogen administration for contraceptive purposes, hormone replacement therapy, prolonged antibiotic usage, and underlying diabetes mellitus (McClelland et al , 2009; Liu
- Recurrent Vulvovaginal Candidiasis: Assessing the relationship between . . .
Our study found a statistically significant association between using feminine vaginal washes and developing RVVC, as the odds of developing RVVC were almost 4 times higher in women who used vaginal washes than in women who did not use feminine vaginal washes
- The Interplay between Candida albicans, Vaginal Mucosa, Host . . . - MDPI
This review provides an overview of the current knowledge regarding the pathogenic mechanisms underlying VVC RVVC, with particular emphasis on the key role played by host innate immunity, vaginal dysbiosis and Candida-related virulence factors We also discuss novel potential therapeutic strategies based on the use of probiotics and vaginal
- An Intravaginal Live Candida Challenge in Humans Leads to New . . .
In the present study, an intravaginal live Candida challenge in healthy adult women showed a differential susceptibility to symptomatic VVC, where 3 (15%) of 19 women with no history of VVC acquired a symptomatic infection compared to 6 (55%) of 11 women with an infrequent history of VVC
- Inflammatory cytokine signalling in vulvovaginal candidiasis: a hot . . .
Immune responses to infections of the vaginal mucosa by Candida species are, however, an exception In the case of vulvovaginal candidiasis (VVC), the inflammatory response is associated with symptomatic disease, rather than that it results in pathogen clearance
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