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guld nyheder:
- Safety and immunogenicity of one versus two doses of the COVID-19 vaccine BNT162b2 for patients with cancer: interim analysis of a . . . - ScienceDirect
In patients with cancer, one dose of the BNT162b2 vaccine yields poor efficacy Immunogenicity increased significantly in patients with solid cancer within 2 weeks of a vaccine boost at day 21 after the first dose These data support prioritisation of patients with cancer for an early (day 21) second dose of the BNT162b2 vaccine
- COVID-19 vaccines in patients with cancer - The Lancet Oncology
In the SOAP-02 study, the authors analysed the safety and efficacy of the BNT162b2 vaccine in 151 patients with cancer (95 with solid cancer and 56 with haematological cancer), as well as in a non-age-matched group of 54 healthy controls, and aimed to understand the impact of the first dose in patients with cancer after 3 weeks 4
- Responses of patients with cancer to mRNA vaccines depend on the time interval between vaccination and last treatment - Journal for ImmunoTherapy . . .
There is a need to address how prior treatments impact mRNA vaccine outcomes Method Therefore, we analyzed the response to BioNTech Pfizer’s anti-SARS-CoV-2 mRNA vaccine in 237 oncology outpatients, which cover a broad spectrum of hematologic malignancies and solid tumors and a variety of treatments
- Clinical efficacy and long-term immunogenicity of an early triple dose regimen of SARS-CoV-2 mRNA vaccination in cancer patients - Annals Singapore
This study is among the first to assess the effect of tumour type and anti-neoplastic treatment in determining vaccine response to the third dose of vaccine in cancer patients, and provide real-world efficacy data on SARS-CoV-2 infections with correlation to the neutralising antibody levels and humoral response
- Improvement of different vaccine delivery systems for cancer therapy | Molecular Cancer | Full Text - BioMed Central
Various vaccine delivery systems such as different routes of immunization and physical chemical delivery methods have been used in cancer therapy with the goal to induce immunity against tumor-associated antigens
- Cancer mRNA vaccines: clinical application progress and challenges
This review summarizes the optimization strategies for cancer mRNA vaccines in preclinical settings, the progress of clinical trials, and the challenges encountered while analyzing various delivery vehicle types, infusion methods, and application cases across different cancer types, highlighting key factors in vaccine design
- Therapeutic Cancer Vaccine and Combinations With Antiangiogenic Therapies and Immune Checkpoint Blockade - Frontiers
This review will list different cancer vaccines, with an emphasis on their targets We highlight the results and limits of vaccine strategies and then describe strategies that combine therapeutic vaccines and antiangiogenic therapies or immune checkpoint blockade
- Fulltext | Vaccines Against Different Types of Cancer: Literature Review
Cancer vaccines can be of different types and fit into active immunotherapy, once all of them induce memory [5] Using the Pubmed database, it was found about 300 papers regarding the use of vaccine for various types of cancers in the last 20 years
- Immunizing Cancer Patients: Which Patients? Which Vaccines? When to Give?
We suggest administering the first dose of the vaccine prior to the onset of cancer-directed therapy or ≥ 3 months after chemotherapy We vaccinate with RZV even patients who have previously received ZVL; the ACIP recommends waiting at least 2 months between the vaccines
- Clinical advances and ongoing trials of mRNA vaccines for cancer treatment
A few trials have reported durable objective responses in patients with cancer after mRNA-based vaccine treatment, without unmanageable toxic effects 10,14–16,19 mRNA vaccines are promising therapeutic candidates for future cancer treatments, especially in combination with additional immunotherapies 14,19,20 However, no phase 3
- Vaccination of Adults With Cancer: ASCO Guideline
Vaccine-naive adult patients with cancer can receive either one dose of PCV-20 only or a dose of PCV-15 followed by a dose of PPSV23, with at least 8 weeks between administrations
- mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer - ScienceDirect
This comprehensive review explores the landscape of mRNA vaccines and their delivery platforms for cancer, addressing design considerations, diverse delivery strategies, and recent advancements Overall, this review contributes to the progress of mRNA vaccines as an innovative strategy for effective cancer treatment
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