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- Recombinant human hyaluronidase (rHuPH20): an enabling platform for . . .
A fully human recombinant DNA-derived hyaluronidase enzyme (rHuPH20) has been developed to leverage the historical efficacy of animal testes extract-derived spreading factors to reversibly modify the hypodermis, in light of discovery of the human hyaluronidase gene family
- rHuPH20 - Overview and Mechanism of Action - Janssen Science
Recombinant human hyaluronidase (rHuPH20) is a purified form of testicular (PH20) hyaluronidase, which does not elicit immunogenic reactions 1-4 When administered subcutaneously (SC), rHuPH20 hydrolyzes hyaluronan in the ECM
- Clinical Immunogenicity of rHuPH20, a Hyaluronidase Enabling . . .
Since rHuPH20 has been used clinically to facilitate dispersion and absorption of several co-administered biotherapeutic agents, it represents a unique opportunity to evaluate immunogenicity in multiple patient populations and dosing regimens
- ENHANZE Drug Delivery Technology - Halozyme
Halozyme’s ENHANZE ® drug delivery technology, which is a proprietary, validated rHuPH20 enzyme paired with our unparalleled expertise in subcutaneous (SC) drug development, has been well-proven to enable rapid, high-volume subcutaneous delivery of co-administered drugs
- Full article: Safety of recombinant human hyaluronidase PH20 for . . .
Recombinant human hyaluronidase PH20 (rHuPH20) acts locally to temporarily remove this barrier, facilitating rapid SC delivery of large volumes and or high doses of sequentially or co-administered therapeutics
- Enhanced hyaluronidase-based drug delivery - Nature
Halozyme’s rHuPH20 depolymerizes HA locally and transiently in the extracellular matrix, which enables the rapid delivery of higher-volume SC injections (2–20 mL) and even larger SC infusions
- Effects of Recombinant Human Hyaluronidase (rHuPH20) on Subcutaneous . . .
RATIONALE: rHuPH20 is a novel drug delivery enzyme that locally degrades hyaluronan and transiently increases bulk fluid flow, thereby facilitating improved subcutaneous (SC) absorption profiles of co-administered agents
- ENHANZE ® drug delivery technology: a novel approach to . . . - PubMed
This article reviews pharmaceutical properties of rHuPH20, its current applications with approved therapeutics, and the potential for future developments
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