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- New Biomarkers Catch Tau Before It Tangles | ALZFORUM
Tau pathology in humans or animals, without fail, is made up of the hyperphosphorylated protein In AD tau is hyperphosphorylated sub-stoichiometrically at multiple sites by several combinations of protein kinases Six isoforms of tau in the human brain and hyperphosphorylation at multiple sites in AD generate numerous protein species
- Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
Tau, Incorporated A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains The degree of incorporation of each mutant into the growing fibrils (middle) is measured via FRET (right) [Courtesy of Vaquer-Alicea et al , Science Advances
- ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
The authors argue that tight binding between ApoE3Ch and tau that prevents fragmentation, plus weak binding between ApoE3Ch and lipoprotein receptor-related protein 1 (LRP1) and heparan sulfate proteoglycans, as reported previously, together prevent ApoE3Ch-bound tau from getting into neurons or microglia, stopping the spread of tau toxicity
- Tau (AT8); Phospho Tau (Ser 202, Thr 205) | ALZFORUM
Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease Recognizes paired helical filament (PHF) tau Phosphorylation at serine 202 and threonine 205 is required for recognition by AT8
- Night-Night, Neurodegeneration: Sleep Aid Lulls Tau Pathology
A different sleep drug, the GABA A modulator zolpidem, had no such effect, with mice bearing the full brunt of tau pathology (image below) Females, whose atrophy was milder, reaped little benefit from either therapy Goodnight, Degeneration: Vehicle-treated P301S E4 mouse show tau’s toll: swollen ventricles and a thinned hippocampus (left
- Organization of Aβ Plaques and Tau Tangles Illuminated in AD Brain
By contrast, tau aggregates were neatly ordered, with uniform, evenly spaced fibrils arranged into bundles Many of these tau filaments resembled the paired helical filaments characteristic of AD But surprisingly, others looked more like fibrils found in people with chronic traumatic encephalopathy (CTE)
- Heavy Tau Snuffs Out Hippocampal Bursts | ALZFORUM
Shushed by Tau Left: In patch-clamp setup, tau from AD brain is loaded into the recording pipette and diffuses into the CA1 neuron with which the pipette has made its seal Middle: Immunofluorescence image showing successful delivery of tau, with biocytin (green) marking the neuron, Tau-13 antibody staining infused tau (red)
- MTBR-243 Tau: A Fluid Biomarker for Tangles Themselves?
However, past tau biomarker studies didn’t find MTBR-tau in CSF, in part because the antibodies available at the time were insufficiently specific or sensitive They instead focused on the parts of tau they could detect, that is, the N-terminal and mid-domain, aka proline-rich region, which are actively secreted from neurons after truncation
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