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- Ligand-gated ion channel - Wikipedia
Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na +, K +, Ca 2+, and or Cl − to pass through the membrane in response to the binding of a chemical messenger (i e a ligand), such as a neurotransmitter
- Ligand-gated ion channels | Pharmacology Education Project
Ligand-gated ion channels (LGICs) mediate passive ion flux driven by the electrochemical gradient for the permeant ions LGICs are gated by the binding of a specific ligand to an orthosteric site(s) that triggers a conformational change that results in the conducting state, or by binding of endogenous, or exogenous, modulators to allosteric sites
- Ion Channels as Targets in Drug Discovery: Outlook and Perspectives
Overview of ligand-gated ion channels Schematic representation of phylogenetic relationship between ligand-gated ion channel superfamilies based on minimal pore regions From: https: www metrionbiosciences com knowledge-library ion-channel-overviews
- 17. Ion Channels – Principles of Pharmacology – Study Guide
pore-forming membrane proteins that allow ions to pass through a channel pore Ligand-Gated Ion Channels – allow ions to flow into or out of the cell in response to the binding of a chemical messenger to their respective receptors
- Ligand-gated ion channels: Structure, types and function - Kenhub
Ligand-gated ion channels, or ionotropic receptors, are integral proteins of the cell membrane that undergo activation upon binding to specific signaling molecules known as ligands This interaction takes place at a binding domain of the channel, facilitating the passage of ions through the channel's pore
- Ion channels, receptors, agonists and antagonists
Ligand-gated ion channels (LGICs) mediate the majority of fast neurotransmission within the CNS Fine tuning of CNS activity is achieved by modulating the activity of inhibitory and excitatory LGICs Many clinically useful neuroactive drugs alter the activity of LGICs
- LIGAND-GATED ION CHANNELS - Guide to Pharmacology
Overview: Ligand-gated ion channels (LGICs) are integral membrane proteins that contain a pore which allows the regulated flow of selected ions across the plasma membrane Ion flux is passive and driven by the electrochemical gradient for the permeant ions
- Ligand-Gated Ion Channels: Synaptic Transmission
Targeting ligand-gated ion channels with drugs is a powerful approach to treating a wide range of diseases, and as our understanding of these fascinating channels continues to grow, we can expect even more sophisticated and effective therapies to emerge
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