Install Free Gold Price Widget!
Install Free Gold Price Widget!
Install Free Gold Price Widget!
|
- Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in . . .
Moreover, we demonstrate that activation of the PI3k Akt pathway mediated by XBP-1 is involved in upregulation of Ets-1, and that inhibition of Ets-1 recapitulates, at least in part, the effect of inhibition of Mcl-1 on sensitivity of melanoma cells to ER stress-induced apoptosis
- Roles of XBP1s in Transcriptional Regulation of Target Genes
Translated XBP1s migrates to the nucleus and regulates the transcriptional programs of UPR target genes encoding ER molecular chaperones, folding enzymes, and ER-associated protein degradation (ERAD) components to decrease ER stress
- Pivotal role of the endoplasmic reticulum stress-related . . .
Our study shows that sustained activation of XBP1s expression in acute myeloid leukemia (AML) cells induces apoptosis in vitro and in vivo, whereas a moderate XBP1s expression sensitizes cells
- Stress management at the ER: Regulators of ER stress-induced . . .
Enzymes mediating post-translational modification of XBP1s are emerging as another group of ER stress regulators and include acetyl transferases and deacetylating enzymes, as well as E3-ligases mediating modification by small ubiquitin-like modifiers (SUMO)
- Roles of XBP1s in Transcriptional Regulation of Target Genes
Translated XBP1s migrates to the nucleus and regulates the transcriptional programs of UPR target genes encoding ER molecular chaperones, folding enzymes, and ER-associated protein degradation (ERAD) components to decrease ER stress
- Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in . . .
We show in this report that transcriptional upregulation of Mcl-1 by ER stress is mediated by Ets-1 that is also upregulated by the IRE1α XBP-1 branch of the UPR
|
|
|